Sa Kamay ng mga Kilabot (1965)- Stars Joseph Estrada, Eddie Garcia, Larry Silva, Ben Dato and Paquito Diaz/ Introducing George Estregan/ Directed by Cesar Gallardo/ Estregan's First Movie
George Estregan was introduced in the movie, Sa Kamay ng mga Kilabot in 1965, with no less than his elder brother Joseph “Erap’ Estrada in the lead role. But it was in 1969 that Estregan was given some important roles. He was tapped to do several challenging roles in succession, all in a starring role in Eric,
He won the Famas Best Actor award in 1972 for the movie Sukdulan; Famas Best Supporting Actor in 1978 for Kid Kaliwete and Lumakad ka ng Hubad sa Mundong Ibabaw in 1981; FAP Best Supporting Actor for Sa Bulaklak ng Apoy in 1985.
Among his memorable movies were three of Ishmael Bernal movies: Huwag Pamarisan: Mister Mo Lover Boy Ko; Lumapit...Lumayo ang Umaga and Nunal sa Tubig. He also played the role of ace police reporter Ruther Batuigas in Paukuin si Waway, a Rudy Fernandez starrer.
He was a consummate and accomplished performer, a versatile and talented actor. But his superb and awesome credential as a top rate actor was somewhat tarnished towards in the latter years of his career when he accepted roles that called for sex and nudity. He allowed himself to be used in several cheap and B-sex flicks, bordering to pornography.
Left- Lover For Hire (1970)- Stars George Estregan, Rosanna Ortiz, Lilia Dizon, Gina Laforteza, Romy Diaz, Roldan Aquino, Avel Morado and Ponga/ Directed by Armando Garces
Right- Udyok (1971)- Stars George Estregan, Eddie Garcia, Imelda Ilanan and Rosanna Ortiz/ Directed by Armando A. Herrera
Left- Durog (1971)- Stars George Estregan, Romy Diaz and Alona Alegre/ Directed by Armando A. Herrera
Right- Kami Ba'y... Makasalanan (1971)- Stars George Estregan, Anna Ledesma, Gina Laforteza and Dolly Fuentes/ Directed by Teodoro P. Recio
Target: The Criminals (1973)- Stars Jun Aristorenas, George Estregan and Virginia/ Directed by Junar